It was a great pleasure for us all to congratulate a PI Member of our ITN, Prof Raj Thakker, on the occasion of his election to be a Fellow of the Royal Society. Thus, a long overdue omission has been corrected.
Professor R.V. Thakker FMedSci FRS
May Professor of Medicine, University of Oxford
For those who might not recognize the significance and gravitas of such an Election, it must be added that, this is the highest science honour and recognition that can be bestowed upon a scientist in the UK. The Royal Society looks back on over 350 years of history; it is the foremost independent scientific academy, learned society in the UK. The Royal Society elects its own Fellows (members), currently less than fifteen hundred, solely on their scientific merit.
RAJESH V THAKKER
Raj’s research has made significant contributions to endocrinology and metabolism, and especially to our understanding of the pathophysiology of parathyroid and kidney disorders that affect calcium homeostasis. His research at the basic science and clinical interface, has resulted in seminal discoveries of genes, with mechanistic insights at the molecular, cellular and physiological levels, that include: identification of functional pathways of calcium-sensing, through characterisation of mutations of the calcium-sensing-receptor, a G-protein coupled- receptor (GPCR), and components of its signalling pathway such as G-protein-alpha-11 subunit (Gα11) and adaptor-protein-2-sigma-subunit (AP2σ), which regulates GPCR endocytosis; and defining new parathyroid and kidney disorders that have established a molecular-based taxonomy with important biological insights into the development of syndromic and non-syndromic forms of parathyroid tumours, as well as the syndromic and non-syndromic forms of hypoparathyroidism and renal tubular physiology of calcium homeostasis. His clinical application of these advances has had a major impact on the diagnosis and treatments for endocrine and renal disorders.