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Calcium Sensing Receptor Symposium


The 2nd International Symposium on The Calcium Sensing Receptor (CaSR)

March 3 – 4, 2015 Omni Hotel, San Diego, California, USA

The symposium will bring together basic, translational, and clinical scientists from different disciplines who study the molecular biology, physiology, and pathophysiology of the CaSR and clinical disorders of CaSR function.

Preliminary Programme of the 2nd International Symposium On The Calcium Sensing Receptor

*All talk titles are tentative and subject to change.

March 3, 2015

7:00-8:00   Networking Breakfast

8:00-8:10 Introduction and Housekeeping: Dolores Shoback

08.10-08.40: Session 1: Keynote Presentation- Basic/Translational: Title TBD

Chair: Wenhan Chang

Keynote Lecture: Gerda Breitwieser (Weis Center for Research, USA)

08.40-10.15: Session 2: Molecular and Cellular Physiology of the CaSR

Co-chairs: Gerda Breitwieser and Christopher Loretz

1. Jenny Yang (Georgia State University, USA): Structure of the CaSR.

2. Christopher Loretz (State University New York, USA): Evolution of the CaSR

3. Geoffrey Hendy (McGill University, Canada): Transcription and translation regulation of the CaSR

4. Hans Brauner-Osborne (University of Copenhagen, Demark): CaSR biased signalling

5. Short-talk #1: Kati Leach (Monash University, Parkville, Australia)

10.15 -10.35 Networking / Coffee break

10.35-11.55: Session 3: CaSR and Parathyroid Function

Co-chairs: Geoffrey Hendy and Edward Brown

1. Arthur Conigrave (University of Sydney, Australia): CaSR and Parathyroid: Past, Present and Future

2. Donald Ward (University of Manchester, UK): CaSR and Parathyroid Cell Signaling

3. Maria Luisa Brandi (University of Florence, Italy): Recent Advances in Parathyroid Cell Secretory Models

4. Wenhan Chang (University of California San Francisco, USA): Parathyroid GABAbR1 and Ca2+-sensing

12:10-13:00  Working Lunch Session: Eat and Listen (Oral Poster Presentation)

Chair: Enikö Kallay

** Oral presentations will be selected from the top scoring abstracts submitted to the conference for an additional 5-minute slide presentation preceding the poster viewing.

13:00-14:00  Poster Viewing

14:00-15:40  Session 4: CaSR and Kidney Function

Co-chairs: William Goodman and Daniela Riccardi

1. Pascal Houillier (Descartes University, Paris, France) Calcilytics and systemic Ca2+ homeostasis

2. Jianghui Hou (Washington University, USA) CaSR, Claudin-14 and Ca2+ transport

3. Hakan Toka (Harvard Medical School, Boston, USA) Lesson learned from kidney-specific CaSR ablation

4. Tyler Miller (Case Western Reserve University, USA) CaSR-dependent regulation of phosphorous and H+

15:40-16:00  Networking Coffee Break

16:00-17:00  Session 5: CaSR and Digestive Function

Co-chairs: Arthur Conigrave and Sam Cheng

1. John Geibel (Yale University, USA): CaSR and parietal cell function

2. Sam Cheng (University of Florida, USA): TBD

3. John MacLeod (Queen’s University, Canada): TBD

17:00-18:15  Session 6: CaSR in Bone and Marrow

Co-chairs: Dolores Shoback and Dengshun Miao

1. David Goltzman (McGill University, Canada): CaSR and VDR in bone

2. Romuald Mentaverri (Université de Picardie Jules Verne, France): CaSR and osteoclast functions

3. Gregor Adams (University of South California, USA): CaSR in multiple myeloma and HSC's functions

4. Short-talk # 2: Mark Rybchyn (University of Sydney, Australia)

18:30-20:30  Networking Dinner/Reception


March 4, 2015

7:00-8:00     Networking Breakfast

8:00-8:30     Session 7: Clinical Keynote Presentation: The calcium-sensing receptor and disorders of extracellular calcium sensing

Chair:  Edward Nemeth

Speaker: Edward Brown

8:30-9:30     Session 8: CaSR Function in Breast, Skin, and inflammation

Chairs: Daniel Bikle and Dolores Shoback

1. John Wysolmerski (Yale University, USA): CaSR in breast physiology and cancer

2. Chia-Ling Tu (University of California San Francisco, USA): CaSR in skin development and wound healing

3. Ulf Wagner (Leipzig University, Germany): CaSR and inflammation

9:30-9:50 Networking Coffee Break

9:50-11:00 Session 9: CaSR Function in the Brain and Blood Vessel

Co-chairs: Wenhan Chang and Stephen Smith

1. Wenhan Chang: Introduction of CaSR in brain physiology and pathology

2. Stephen Smith (Oregon Health & Science University, USA): CaSR and ion channel regulation in neurons

3. Ubaldo Armato (University of Verona, Italy): CaSR, astrocytes and alzheimer's

4. Short-talk #3: Martin Schepelmann (University of Cardiff, UK)

11:00-12:10  Session 10: CaSR and Cancer

Co-chairs: Enikö Kallay and John Wysolmerski

1. Eniko Kallay (Medical University Vienna, Austria): introduction and overview of CaSR and Cancer

2. Daniel Bikle (University of California San Francisco, USA): CaSR and VDR in skin cancer

3. Osvaldo Rey (National Research Council (CONICET), Argentina): CaSR and colon cancer

4. Short talk #4: TBD

5. Short talk #5: TBD

12:10-14:00 Lunch and Poster Viewing

12:10-13:00 Young Investigator Session: Lunch with CaSR Senior Investigators

14:00-15:40 Session 11: Treatment of Hyperparathyroidism with Calcimimetics

Co-chairs:   Edward Nemeth and Masafumi Fukagawa

1. Glenn Chertow (Stanford University, USA): Cinacalcet and cardiovascular outcomes (invited)

2. Masafumi Fukagawa (Tokai University School of Medicine, USA): Cinacalcet, FGF-23/Klotho, and parathyroid hyperplasia

3. Dolores Shoback (University of California San Francisco, USA): Cinacalcet and primary HPT

4. Geoff Block: AMG 416

15:40-16:30  Session 12:  Genetic Disorders of the CaSR

Co-chairs:  Maria Luisa Brandi and Raj Thakker

1. Rajesh Thakker (University of Oxford, UK): Familial hypocalciuric hypercalcemia type 1-3

2. Michael Mannstadt (Harvard University, USA): Autosomal dominant hypocalcaemia types 1 and 2

16:30-16:50  Networking Coffee Break

16:50-18:30  Session 13: New Implications for Calcimimetics and Calcilytics

Co-chairs: Arthur Conigrave and Edward Nemeth

1. Edward Nemeth (MetisMedica, Canada): CaSR as therapeutic target

2. Daniela Riccardi (Cardiff University, UK): CaSR as a therapeutic target for asthma

3. Jason Yuan (University of Arizona, USA): CaSR as therapeutic target for pulmonary arterial hypertension

4. Fadil Hannan (University of Liverpool, UK): CaSR and glucose metabolism in Nuf mice

18:30-19:30 Closing Remarks and Reception

Members of Organizing Committee:

  • Maria-Luisa BRANDI (Italy)
  • Edward BROWN (USA)
  • Wenhan CHANG (USA)
  • Arthur CONIGRAVE (AUS)
  • William GOODMAN (USA)
  • Geoffrey HENDY (Canada)
  • Enikö KALLAY (Austria)
  • Christopher LORETZ ( USA)
  • Dengshun MIAO (China)
  • Edward NEMETH (Canada) – co-chair
  • Daniela RICCARDI (UK)
  • Masafumi FUKAGAWA (Japan)
  • Dolores SHOBACK (USA) – co-chair
  • Rajesh V. THAKKER (UK)
  • Chialing TU (USA)
  • Newton ONG (USA) - Lead Administrator

The program will feature recent research on the role of the CaSR in skeletal development and physiology, vascular calcification, pulmonary function, neuronal injury, neuroendocrine control mechanisms, parathyroid physiology, mineral metabolism, exocrine and transport functions in the gut and kidney, and cancer cell signalling. Clinical uses of CaSR modulators to treat human disorders, evolutionary aspects of the CaSR, and interactions between the CaSR and vitamin D will be highlights.

The program will include lectures from keynote speakers, oral abstract presentations, poster discussion sessions, and forums for young investigators to meet senior experts.

The Conference starts Tuesday, March 3 at 8:30 am, and ends Wednesday, March 4 at 5:00 pm.


1st CaSR Symposion 2012 =======================================

Vienna, Nov. 30 – Dec. 1, 2012
Venue Tech Gate
Donau-City-Straße 1
1220 Wien


Aim of the Symposium

The main objective of this Conference is to bring together for the first time experts, basic and translational scientists from across different disciplines studying the Physiology and Pathophysiology of the Extracellular Calcium Sensing Receptor.

PROGRAM - Symposium on Calcium Sensing Receptor


08.30 - 08.35: Welcome Address
Chair: E. Kallay, E.M. Brown

08.35 - 10.00: Session1: Physiology and Pathology of CaSR Signalling
Chair: A. Conigrave, S. Price

08.35 - 09.05: Keynote Lecture: O50 - Dynamic phosphorylation of the calcium-sensing receptor as a determinant of extracellular calcium homeostasis
D. Ward

09.05 - 09.15: O51 - Molecular basis of constitutively active variants of the calcium-sensing receptor (CaSR)
M. Ranieri, G.Tamma, A. Di Mise, G. Vezzoli, L. Soldati, M. Svelto, G. Valenti

09.15 - 09.30: O52 - The endoplasmic reticulum (ER)-quality control protein, OS-9, specifically recognizes immature processed forms of the calcium-sensing receptor (CaSR) and influences receptor cell-surface expression
B. Ward, A. Magno, A. Arulpragasam, S. Chew, V. Joshi, B. Pedersen, E. Ingley, A. Conigrave, T. Ratajczak

09.30 - 10.00: Keynote Lecture: O53 - Calcimimetic and Calcilytic Drugs
E. F. Nemeth


10.00 - 10.30: Coffee Break


10.30 - 11.30: Session 1b: Physiology and Pathology of CaSR Signalling
Chair: F. Bruggeman, E.M. Brown

10.30 - 11.00: Invited Lecture: O54 - The intimate link between Calcium Sensing Receptor Trafficking and Signaling
M. P. Grant, A. Stepanchick, A. Cavanaugh, G. E. Breitwieser

11.00 - 11.10: O55 - Regulation of signalling pathways by extracellular calcium in colon cancer cells
S. Tennakoon, B. Marian, J. Schmid, E. Kallay

11.10 - 11.30: Invited Lecture: O56 - Modulation of cAMP and cAMP-sensitive signaling by the calcium-sensing receptor
A. D. Conigrave, V. A. Avlani, A. Christopoulos, H.-C. Mun

11.30 - 12.50: Session 2: Role of the CaSR in Cancer
Chair: E. Kallay, R. Mentaverri

11.30 - 12.00: Keynote Lecture: O57 - Is Calcium-sensing Receptor a Double-Edged Sword in Cancer?
N. Chattopadhyay

12.00 - 12.10: O58 – Involvement of epigenetic mechanisms in regulating expression of the calcium sensing receptor in colorectal cancer
I. Sh. Fetahu, J. Höbaus, C. Gröschel, S. Tennakoon, T. Manhardt, I. Mesteri, S. Baumgartner-Parzer, E. Kallay

12.10 - 12.20: O59 – Involvement of the calcium sensing receptor in colorectal cancer proliferation
A. Aggarwal, J. Höbaus, I. Sh. Fetahu, I. Mesteri, E. Kallay

12.20 - 12.30: O60 - The calcium-sensing receptor is silenced by genetic and epigenetic mechanisms in unfavorable neuroblastomas and its reactivation induces ERK1/2-dependent apoptosis
C. Casalà, E. Gil-Guiñón, J. L. Ordóñez, S. Miguel-Queralt, E. Rodríguez, P. Galván, C. Lavarino, F. Munell, E. de Alava, J. Mora, C. de Torres

12.30 - 12.50: O61 - Effect of increased dietary calcium on murine colonic CaSR expression and the effect of induced colitis on "rescued" CaSR-/PTH- (C-/P-) knockout mice
R. Turki, J. E. Kelly, I. Pacheco, R. J. MacLeod


12.50 - 14.00: Lunch


14.00 - 15.45: Session 3: Role of CaSR in Vascular Calcification
Chair: R. Thakker, M. Peterlik

14.00 - 14.30: Keynote lecture: O62 - The role of the calcium-sensing receptor (CaSR) in chronic kidney disease
T. B. Drüeke

14.30 - 14.40: O63 - Role of calcium sensing receptor on monocyte migration and vascular calcification related to atherosclerosis
I. Lopez, L. Henaut, C. Boudot, M. Brazier, R. Mentaverri

14.40 - 14.50: O64 - A mouse model of targeted deletion of the calcium sensing receptor (CaSR) from vascular smooth muscle cells implicates the CaSR in vascular pathophysiology
M. Schepelmann, T. Davies, P. Yarova, S. Brennan, W. Chang, D. Bikle, M. Krssak, T. Wells, A. Stewart, B. van der Kolk, B. Monk, D. Ward, A. Canfield, D. Edwards, P. Kemp, D. Riccardi

14.50 - 15:00: O65 - An investigation of the role of calcimimetics in a murine model of targeted deletion of the calcium-sensing receptor, CaSR, from vascular smooth muscle cells (SM22α x fl CaSR)
T. Davies, M. Schepelmann, S. Brennan, P. Yarova, W. Chang, D. Bikle, W. Richards, D. T. Ward, A. E. Canfield, D.Edwards, P. Kemp, D. Riccardi

15.00 - 15.15: O66 - Expression of the calcium sensing receptor maintains vascular smooth muscle cell phenotype and prevents calcification
G. Molostvov, D. Zehnder, R. Bland

15.15 - 15.25: O67 - Association of calcium-sensing receptor polymorphisms with indices of vascular calcification in renal transplant recipients
V. N. Babinsky, F. M. Hannan, S. Youhanna, O. Devuyst, R. V. Thakker

15.25 - 15.35: O68 - Polymorphisms of CaSR gene decreasing CaSR expression predispose to calcium nephrolithiasis
G. Vezzoli, A. Aloia, A. Terranegra, E. Dogliotti, T. Arcidiacono, F. Rainone, A. Mingione, D. Spotti, D. Cusi, G.N. Hendy, L. Soldati

15.35 - 15.55: Invited Lecture: O69 – O69 – Roles of the Calcium-Sensing Receptor (CaSR) in Calcium and Phosphate Homeostasis: Studies in Knockout Mouse Models
M. Rodriguez, Hospital Universitario Reina Sofia, Cordoba, Spain


15.55 - 16.30: Coffee Break


16.30 - 18.30: Session 4: Role of the CaSR in Bone Development and Physiology
Chair: D. Riccardi, M.L. Brandi, K. Klaushofer

16.30 - 17.00: Keynote Lecture: O70 - The calcium sensing receptor and bone metabolism
P. J. Marie

17.00 - 17.20: O71 - Clinical Consequences of CASR Mutation in the First Few Years of Life
D. E. C. Cole, G. N. Hendy

17.20 - 17.30: O72 - Extracellular Ca2+ and the extracellular calcium-sensing receptor are important regulators of fetal lung Development
S. C. Brennan, W. J. Wilkinson, B. A. Finney, H.-E. Tseng, B. Monk, R. L. Townsend, M. Lazarou, D. Adriansen, E. Jesudason, D. Warburton, P. J. Kemp, D. Riccardi

17.30 - 17.50: O73 - Calcium sensing receptor and obesity: influence on adipose tissue dysfunction
M. Cifuentes, A. Arreguin, M. Reyes

17.50 - 18.10: O74 - Neuronal CaSRs Regulate General Growth, Skeletal Development, and Energy Homeostasis
J. Park, Z. Cheng, H. Lee, J.-Y. Kim, C. Tu, W. Chang

18.10 - 18.30: O75 - Analysis of calcium-sensing receptor mutations reveal novel structurefunction relationships
F. Hannan, M. A. Nesbit, C. Zhang, T. Cranston, P. Christie, C. Fratter, E. Brown, J. Yang, R. Thakker

18.30 - 18.50: O76 - Structural Biology of Receptor-Mediated Extracellular Calcium Signaling
C. Zhang, Y. Huang, Y. Zhuo, Y. Jiang, H. Strachan, N. Mulpuri, D. Hamelberg, K. Moremen, E. Brown and J. J. Yang

18.50 - 19.00: Closing Remarks

To the program of the International Conference on Progress in Bone and Mineral Research 2012 and the Annual Autumn Conference of the Austrian Society for Bone and Mineral Research including a Symposium on Calcium Sensing Receptor on the occasion of the Awarding of the "2012 International Research Prize"

Organising Committee

Enikö Kallay, Medical University of Vienna, Austria (Chair)
Klaus Klaushofer, Ludwig Boltzmann Institute of Osteology, Vienna, Austria
Peter Mikosch, Ludwig Boltzmann Institute of Osteology, Vienna, Austria
Maria Luisa Brandi, University of Florence, Italy
Frank Bruggeman, Vrije University, Amsterdam, The Netherlands
Rajesh V. Thakker, University of Oxford, UK
Romuald Mentaverri, Université de Picardie Jules Verne, Amiens, France
Daniela Riccardi, University of Cardiff, UK
Sally Price, AstraZeneca UK Limited
Meinrad Peterlik, Medical University of Vienna, Austria
Edward M Brown, Harvard University, USA
Arthur Conigrave, University of Sidney, Australia


Registration Fees:

Payment received
before Oct. 1, 2012 after Oct. 1, 2012
Regular participants EUR 200.- EUR 250.-
Students and Trainees EUR 100.- EUR 150.-
Day Pass EUR 100.-






(Confirmation by supervisor necessary)
No refunds will be possible after November 15, 2012


Dates to remember:

February 2012
Second announcement and call for abstracts

June 29, 2012
Deadline for receipt of abstracts

October 1, 2012
Deadline for early registration

Nov. 29 – Dec. 1, 2012
International Conference in Vienna
The organizers acknowledge the following companies,
organizations and individuals for their support
(as by - subject to change)


Multifaceted CaSR is a Marie Curie Action
funded by the European Commission
under the 7th Framework Programme

Official Sponsors of the 1st CaSR Symposium

Sponsors of the first CaSR Symposium





Flyer 3rd Symposium on CaSR